Induction and Monitoring of Active Delayed Type Hypersensitivity (DTH) in Rats
نویسندگان
چکیده
منابع مشابه
Induction and monitoring of active delayed type hypersensitivity (DTH) in rats.
Delayed type hypersensitivity (DTH) is an inflammatory reaction mediated by CCR7- effector memory T lymphocytes that infiltrate the site of injection of an antigen against which the immune system has been primed. The inflammatory reaction is characterized by redness and swelling of the site of antigenic challenge. It is a convenient model to determine the in vivo efficacy of immunosuppressants....
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Delayed type hypersensitivity (DTH) is an inflammatory reaction mediated by CCR7- effector memory T lymphocytes that infiltrate the site of injection of an antigen against which the immune system has been primed. The inflammatory reaction is characterized by redness and swelling of the site of antigenic challenge. It is a convenient model to determine the in vivo efficacy of immunosuppressants....
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We had previously shown that the local lymphocytic choriomeningitis virus-induced delayed-type hypersensitivity (DTH) reaction in mice consists of two well delineated phases that are mediated by CD8+ and CD4+ T lymphocytes, respectively. These findings have been confirmed and extended by showing that the first CD8+ cell-dependent part of the response was enhanced by either the presence of CD4+ ...
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Delayed-type hypersensitivity (DTH) 1 is a T cell-mediated reaction resulting in a mononuclear cell-rich inf lammat ion and swelling that peak 24-48 h after local antigenic challenge. In spite of the extensive use of D T H to dissect regulatory (1), genetic (2), and molecular (3) aspects of in vivo T cell responses, little is known of factors that regulate the persistence o f these reactions. I...
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INTRODUCTION Delayed-type hypersensitivity (DTH) testing is an in vivo assessment of cell-mediated immunity. Although highly active antiretroviral therapy (HAART) improves immunologic parameters, the relationship between DTH responsiveness and CD4 gains on HAART is not completely understood. We investigated CD4 reconstitution and the change in DTH responses from treatment baseline through 24 mo...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2007
ISSN: 1940-087X
DOI: 10.3791/237